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The Importance of Murine Models in Determining In Vivo Pharmacokinetics, Safety, and Efficacy in Antimalarial Drug Discovery

It has been the subject of hundreds of published preclinical studies examining its effects across multiple tissue types

Among those drugs, the combination of Dasatinib (D), a pan-inhibitor of tyrosine kinase receptors and Quercitin (Q), a flavonoid compound extract from plants targeting BCL-2 family members, is one of the most characterized as well as one of the most used in clinical trials to eliminate senescent cells

In the future, human clinical trials will help to clarify the efficacy of antioxidants as potential therapies for infertility

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